Antioxidant Potential of Antiviral Drug Umifenovir.
Identifieur interne : 000756 ( Main/Exploration ); précédent : 000755; suivant : 000757Antioxidant Potential of Antiviral Drug Umifenovir.
Auteurs : Elena V. Proskurnina [Russie] ; Dmitry Yu Izmailov [Russie] ; Madina M. Sozarukova [Russie] ; Tatiana A. Zhuravleva [Russie] ; Irina A. Leneva [Russie] ; Artem A. Poromov [Russie]Source :
- Molecules (Basel, Switzerland) [ 1420-3049 ] ; 2020.
Abstract
Free radical reactions play an important role in biological functions of living systems. The balance between oxidants and antioxidants is necessary for the normal homeostasis of cells and organisms. Experimental works demonstrate the role of oxidative stress that is caused by influenza virus as well as the toxic effects of some antiviral drugs. Therefore, antiviral drugs should be characterized by its pro- and antioxidant activity, because it can affect its therapeutic efficiency. The aim of the study was to quantify the antioxidant capacity and propose the mechanism of the antioxidant effect of the antiviral drug Umifenovir (Arbidol®). The kinetic chemiluminescence with the 2,2'-azobis (2-amidinopropane) dihydrochloride + luminol system was used to quantify the antioxidant capacity of Umifenovir relative to the standard compound Trolox. With computer simulation, the reaction scheme and rate constants were proposed. The antioxidant capacity of 0.9 μM Umifenovir (maximum concentration of Umifenovir in blood after oral administration of 200 mg) was as high as 1.65 ± 0.18 μM of Trolox. Thus, the total antioxidant capacity of Umifenovir is comparable to the antioxidant capacity of Trolox. Unlike Trolox, Umifenovir reacts with free radicals in two stages. For Trolox, the free radical scavenging rate constant was k = 2000 nM-1 min.-1, for Umifenovir k1 = 300 nM-1min.-1, k2 = 4 nM-1min.-1. Slower kinetics of Umifenovir provides the prolonged antioxidant effect when compared to Trolox. This phenomenon can make a serious contribution to the compensation of oxidative stress that is caused by a viral disease and the therapeutic effect of the drug.
DOI: 10.3390/molecules25071577
PubMed: 32235534
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000120
- to stream PubMed, to step Curation: 000120
- to stream PubMed, to step Checkpoint: 000160
- to stream Ncbi, to step Merge: 000C38
- to stream Ncbi, to step Curation: 000C38
- to stream Ncbi, to step Checkpoint: 000C38
- to stream Main, to step Merge: 000757
- to stream Main, to step Curation: 000756
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antioxidant Potential of Antiviral Drug Umifenovir.</title>
<author><name sortKey="Proskurnina, Elena V" sort="Proskurnina, Elena V" uniqKey="Proskurnina E" first="Elena V" last="Proskurnina">Elena V. Proskurnina</name>
<affiliation wicri:level="1"><nlm:affiliation>Research Centre for Medical Genetics, ul. Moskvorechye 1, Moscow115522, Russia.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Research Centre for Medical Genetics, ul. Moskvorechye 1, Moscow115522</wicri:regionArea>
<wicri:noRegion>Moscow115522</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Izmailov, Dmitry Yu" sort="Izmailov, Dmitry Yu" uniqKey="Izmailov D" first="Dmitry Yu" last="Izmailov">Dmitry Yu Izmailov</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Fundamental Medicine, Lomonosov Moscow State University, Lomonosovsky prospekt 27-1, Moscow 119234, Russia.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Faculty of Fundamental Medicine, Lomonosov Moscow State University, Lomonosovsky prospekt 27-1, Moscow 119234</wicri:regionArea>
<placeName><settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sozarukova, Madina M" sort="Sozarukova, Madina M" uniqKey="Sozarukova M" first="Madina M" last="Sozarukova">Madina M. Sozarukova</name>
<affiliation wicri:level="1"><nlm:affiliation>Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninsky prospekt 31, Moscow 119991, Russia.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninsky prospekt 31, Moscow 119991</wicri:regionArea>
<placeName><settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhuravleva, Tatiana A" sort="Zhuravleva, Tatiana A" uniqKey="Zhuravleva T" first="Tatiana A" last="Zhuravleva">Tatiana A. Zhuravleva</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Fundamental Medicine, Lomonosov Moscow State University, Lomonosovsky prospekt 27-1, Moscow 119234, Russia.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Faculty of Fundamental Medicine, Lomonosov Moscow State University, Lomonosovsky prospekt 27-1, Moscow 119234</wicri:regionArea>
<placeName><settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leneva, Irina A" sort="Leneva, Irina A" uniqKey="Leneva I" first="Irina A" last="Leneva">Irina A. Leneva</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Virology, Mechnikov Research Institute for Vaccines and Sera, Malyi Kazennyi pereulok 5a, Moscow105064, Russia.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Department of Experimental Virology, Mechnikov Research Institute for Vaccines and Sera, Malyi Kazennyi pereulok 5a, Moscow105064</wicri:regionArea>
<wicri:noRegion>Moscow105064</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Poromov, Artem A" sort="Poromov, Artem A" uniqKey="Poromov A" first="Artem A" last="Poromov">Artem A. Poromov</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Virology, Mechnikov Research Institute for Vaccines and Sera, Malyi Kazennyi pereulok 5a, Moscow105064, Russia.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Department of Experimental Virology, Mechnikov Research Institute for Vaccines and Sera, Malyi Kazennyi pereulok 5a, Moscow105064</wicri:regionArea>
<wicri:noRegion>Moscow105064</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:32235534</idno>
<idno type="pmid">32235534</idno>
<idno type="doi">10.3390/molecules25071577</idno>
<idno type="wicri:Area/PubMed/Corpus">000120</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000120</idno>
<idno type="wicri:Area/PubMed/Curation">000120</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000120</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000160</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000160</idno>
<idno type="wicri:Area/Ncbi/Merge">000C38</idno>
<idno type="wicri:Area/Ncbi/Curation">000C38</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000C38</idno>
<idno type="wicri:Area/Main/Merge">000757</idno>
<idno type="wicri:Area/Main/Curation">000756</idno>
<idno type="wicri:Area/Main/Exploration">000756</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Antioxidant Potential of Antiviral Drug Umifenovir.</title>
<author><name sortKey="Proskurnina, Elena V" sort="Proskurnina, Elena V" uniqKey="Proskurnina E" first="Elena V" last="Proskurnina">Elena V. Proskurnina</name>
<affiliation wicri:level="1"><nlm:affiliation>Research Centre for Medical Genetics, ul. Moskvorechye 1, Moscow115522, Russia.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Research Centre for Medical Genetics, ul. Moskvorechye 1, Moscow115522</wicri:regionArea>
<wicri:noRegion>Moscow115522</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Izmailov, Dmitry Yu" sort="Izmailov, Dmitry Yu" uniqKey="Izmailov D" first="Dmitry Yu" last="Izmailov">Dmitry Yu Izmailov</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Fundamental Medicine, Lomonosov Moscow State University, Lomonosovsky prospekt 27-1, Moscow 119234, Russia.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Faculty of Fundamental Medicine, Lomonosov Moscow State University, Lomonosovsky prospekt 27-1, Moscow 119234</wicri:regionArea>
<placeName><settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sozarukova, Madina M" sort="Sozarukova, Madina M" uniqKey="Sozarukova M" first="Madina M" last="Sozarukova">Madina M. Sozarukova</name>
<affiliation wicri:level="1"><nlm:affiliation>Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninsky prospekt 31, Moscow 119991, Russia.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninsky prospekt 31, Moscow 119991</wicri:regionArea>
<placeName><settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhuravleva, Tatiana A" sort="Zhuravleva, Tatiana A" uniqKey="Zhuravleva T" first="Tatiana A" last="Zhuravleva">Tatiana A. Zhuravleva</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Fundamental Medicine, Lomonosov Moscow State University, Lomonosovsky prospekt 27-1, Moscow 119234, Russia.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Faculty of Fundamental Medicine, Lomonosov Moscow State University, Lomonosovsky prospekt 27-1, Moscow 119234</wicri:regionArea>
<placeName><settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leneva, Irina A" sort="Leneva, Irina A" uniqKey="Leneva I" first="Irina A" last="Leneva">Irina A. Leneva</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Virology, Mechnikov Research Institute for Vaccines and Sera, Malyi Kazennyi pereulok 5a, Moscow105064, Russia.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Department of Experimental Virology, Mechnikov Research Institute for Vaccines and Sera, Malyi Kazennyi pereulok 5a, Moscow105064</wicri:regionArea>
<wicri:noRegion>Moscow105064</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Poromov, Artem A" sort="Poromov, Artem A" uniqKey="Poromov A" first="Artem A" last="Poromov">Artem A. Poromov</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Experimental Virology, Mechnikov Research Institute for Vaccines and Sera, Malyi Kazennyi pereulok 5a, Moscow105064, Russia.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Department of Experimental Virology, Mechnikov Research Institute for Vaccines and Sera, Malyi Kazennyi pereulok 5a, Moscow105064</wicri:regionArea>
<wicri:noRegion>Moscow105064</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Molecules (Basel, Switzerland)</title>
<idno type="eISSN">1420-3049</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Free radical reactions play an important role in biological functions of living systems. The balance between oxidants and antioxidants is necessary for the normal homeostasis of cells and organisms. Experimental works demonstrate the role of oxidative stress that is caused by influenza virus as well as the toxic effects of some antiviral drugs. Therefore, antiviral drugs should be characterized by its pro- and antioxidant activity, because it can affect its therapeutic efficiency. The aim of the study was to quantify the antioxidant capacity and propose the mechanism of the antioxidant effect of the antiviral drug Umifenovir (Arbidol<sup>®</sup>
). The kinetic chemiluminescence with the 2,2'-azobis (2-amidinopropane) dihydrochloride + luminol system was used to quantify the antioxidant capacity of Umifenovir relative to the standard compound Trolox. With computer simulation, the reaction scheme and rate constants were proposed. The antioxidant capacity of 0.9 μM Umifenovir (maximum concentration of Umifenovir in blood after oral administration of 200 mg) was as high as 1.65 ± 0.18 μM of Trolox. Thus, the total antioxidant capacity of Umifenovir is comparable to the antioxidant capacity of Trolox. Unlike Trolox, Umifenovir reacts with free radicals in two stages. For Trolox, the free radical scavenging rate constant was <i>k</i>
= 2000 nM<sup>-1</sup>
min.<sup>-1</sup>
, for Umifenovir <i>k</i>
<sub>1</sub>
= 300 nM<sup>-1</sup>
min.<sup>-1</sup>
, <i>k</i>
<sub>2</sub>
= 4 nM<sup>-1</sup>
min.<sup>-1</sup>
. Slower kinetics of Umifenovir provides the prolonged antioxidant effect when compared to Trolox. This phenomenon can make a serious contribution to the compensation of oxidative stress that is caused by a viral disease and the therapeutic effect of the drug.</div>
</front>
</TEI>
<affiliations><list><country><li>Russie</li>
</country>
<region><li>District fédéral central</li>
</region>
<settlement><li>Moscou</li>
</settlement>
</list>
<tree><country name="Russie"><noRegion><name sortKey="Proskurnina, Elena V" sort="Proskurnina, Elena V" uniqKey="Proskurnina E" first="Elena V" last="Proskurnina">Elena V. Proskurnina</name>
</noRegion>
<name sortKey="Izmailov, Dmitry Yu" sort="Izmailov, Dmitry Yu" uniqKey="Izmailov D" first="Dmitry Yu" last="Izmailov">Dmitry Yu Izmailov</name>
<name sortKey="Leneva, Irina A" sort="Leneva, Irina A" uniqKey="Leneva I" first="Irina A" last="Leneva">Irina A. Leneva</name>
<name sortKey="Poromov, Artem A" sort="Poromov, Artem A" uniqKey="Poromov A" first="Artem A" last="Poromov">Artem A. Poromov</name>
<name sortKey="Sozarukova, Madina M" sort="Sozarukova, Madina M" uniqKey="Sozarukova M" first="Madina M" last="Sozarukova">Madina M. Sozarukova</name>
<name sortKey="Zhuravleva, Tatiana A" sort="Zhuravleva, Tatiana A" uniqKey="Zhuravleva T" first="Tatiana A" last="Zhuravleva">Tatiana A. Zhuravleva</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000756 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000756 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= StressCovidV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:32235534 |texte= Antioxidant Potential of Antiviral Drug Umifenovir. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32235534" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a StressCovidV1
This area was generated with Dilib version V0.6.33. |